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Automated synthesizing apparatus
U.S. Patent Number: 5316728
Abstract: an automated synthesizing apparatus which comprises a raw material, reagent and solvent supply unit, a reaction unit, a purification unit provided with HPLC and CPC, and a freeze-drying unit for freeze-drying a purified product supplied from the purification unit. The raw material, reagent and solvent supply unit includes a plurality of reservoirs for containing raw material, reagents and solvents; volumetric tubes and gas-liquid boundary sensors for the quantification of the raw material, reagents and solvents from the reservoirs; flow-lines for supplying the raw material, reagent and solvent from the reservoirs towards subsequent steps; and solenoid valve assemblies disposed on the respective flow-lines for selectively closing and opening such respective flow-lines. The reaction unit includes a reaction flask device adapted to receive the raw material from the raw material, reagent and solvent supply unit; a separation funnel for extracting or washing a product which is transferred from the reaction flask device; a pH adjusting flask for adjusting acidity or basicity of the reaction liquid from the separation funnel; a plurality of reagent reservoirs disposed for adding a predetermined quantity of reagent to the reaction flask device, volumetric tubes and gas-liquid boundary sensors. All of the units, the sensors and the solenoid valve assemblies of each of the units are so connected with a computer that the sequence of operation thereof can be controlled thereby.
Inventors: Hayashi; Nobuyoshi (Kawanishi, JP), Sugawara; Tohru (Osaka, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number: 08/055,786
Issued: 1994-05-31
Expired: 2006-05-31
Classes: 422/70 ; 422/135; 422/138; 422/62; 422/63; 422/67; 422/81; 436/161; 436/180; 436/55
Field of search: 422/62,63,68.1,70,81,106,107,108,67,135,138 435/290,291 436/43,52,55,161,163,808,180
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