Synthetic yeast leader peptides

U.S. Patent Number: 5316923

Abstract: Synthetic leaders for effective secretion of proteins in yeast are provided. Also provided are replicable yeast vectors containing a DNA-sequence encoding the synthetic leader positioned upstream to a DNA-sequence encoding the desired product and operably connected with promoter and signal sequences. There are also provided yeast strains transformed with such vectors and a method for producing proteins by means of the transformed yeast strains.

Inventors: Christiansen; Lars (Lyngby, DK)

Assignee: Novo Nordisk A/S (Bagsvaerd, DK)

Application Number: 07/973,483

Issued: 1994-05-31

Expired: 2006-05-31

Classes: 435/69.9 ; 435/320.1; 530/324; 536/23.7

Field of search: 435/69.9,320.1,254,255,256 536/23.1,23.4,23.7 530/324

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