Sustained release microcapsule

U.S. Patent Number: 5330767

Abstract: Microcapsules are advantageously produced with high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a polymer-containing solution as the oil phase, dispersing said emulsion in an aqueous phase and subjecting the resulting W/O/W emulsion to an in-water drying, wherein the viscosity of the W/O emulsion used in preparing the W/O/W emulsion is adjusted to about 150 to about 10,000 centipoises.

Inventors: Yamamoto; Masaki (Osaka, JP), Takada; Shigeyuki (Osaka, JP), Ogawa; Yasuaki (Osaka, JP)

Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)

Application Number: 07/936,726

Issued: 1994-07-19

Expired: 2006-07-19

Classes: 424/497 ; 424/461; 428/402.2; 428/402.21; 428/402.22; 514/963

Field of search: 264/4.1,4.6 428/402.2,402.21,402.22 424/461,462,486,493,497 514/963,965

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