Complexes possessing ortho ligating functionality

U.S. Patent Number: 5342604

Abstract: A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The chelants possess the general formula ##STR1## wherein R.sup.'1, R.sup.'2, R.sup.'3, R.sup.'4, R.sup.'5 and R.sup.'6, Z' and X are all defined in the specification. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.

Inventors: Wilson; David A. (Richwood, TX), Garlich; Joseph R. (Lake Jackson, TX), Frank; R. Keith (Lake Jackson, TX), McMillan; Kenneth (Richwood, TX), Simon; Jaime (Angleton, TX)

Assignee: The Dow Chemical Company (Midland, MI)

Application Number: 07/900,808

Issued: 1994-08-30

Expired: 2006-08-30

Classes: 424/1.65 ; 534/10

Field of search: 424/1.65 534/10,14,16 562/443

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