N,N-diacylpiperazine tachykinin antagonists

U.S. Patent Number: 5344830

Abstract: Diacylpiperazines of general structure ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.

Inventors: Mills; Sander G. (Woodbridge, NJ), Budhu; Richard J. (Monmouth Junction, NJ), Dorn; Conrad P. (Plainfield, NJ), Greenlee; William J. (Teaneck, NJ), MacCoss; Malcolm (Freehold, NJ), Wu; Mu T. (Clark, NJ)

Assignee: Merck & Co., Inc. (Rahway, NJ)

Application Number: 07/988,514

Issued: 1994-09-06

Expired: 2006-09-06

Classes: 514/235.8 ; 514/227.8; 514/228.2; 514/232.5; 514/253.13; 514/255.01; 544/121; 544/336; 544/357; 544/360; 544/361; 544/372; 544/387; 544/388; 544/390; 544/60; 558/390; 560/157; 560/25

Field of search: 544/387,388,360,60,121,357,372,361 514/227.8,228.2,232.5,235.8,252,253,255

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