5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents

U.S. Patent Number: 5348957

Abstract: The present invention compounds are 5-hydroxy-2-pyrimidinylmethylene derivatives and pharmaceutically acceptable addition salts, bases, and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of, for example, inflammation and GI ulcers.

Inventors: Belliotti; Thomas R. (Ypsilanti, MI), Connor; David T. (Ann Arbor, MI), Kostlan; Catherine R. (Saline, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/103,462

Issued: 1994-09-20

Expired: 2006-09-20

Classes: 514/235.8 ; 514/252.14; 514/269

Field of search: 514/269,235.8,255

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