A87689 compounds employed as a phospholipase A.sub.2 (PLA.sub.2) inhibitor to treat inflammatory diseases

U.S. Patent Number: 5350579

Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.

Inventors: Berry; Dennis R. (Greenwood, IN), Dantzig; Anne H. (Crawfordsville, IN), Debono; Manuel (Indianapolis, IN), Hamill; Robert (Greenwood, IN), Molloy; R. Michael (Danville, IN), Yao; Raymond C. (Carmel, IN)

Assignee: Eli Lilly and Company (Indianapolis, IN)

Application Number: 08/103,845

Issued: 1994-09-27

Expired: 2006-09-27

Classes: 424/122 ; 435/195; 435/252.1; 435/253.2; 435/253.5

Field of search: 424/122 435/252.1,195,253.2,253.5

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