3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion

U.S. Patent Number: 5350748

Abstract: 3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described. The same benzo[b]thiophene and benzofuran-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected mammals.

Inventors: Boschelli; Diane H. (Plymouth, MI), Connor; David T. (Ann Arbor, MI), Kramer; James B. (Sylvania, OH), Unangst; Paul C. (Ann Arbor, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/108,951

Issued: 1994-09-27

Expired: 2006-09-27

Classes: 514/237.2 ; 514/231.5; 514/233.5; 514/445; 544/146

Field of search: 549/52,55,53,54,57 514/443,444,445,446,447,448,237.2,233.5,231.5 544/146,145

Click the image above to view patent images at uspto.gov within a frame.

Click here for the fulltext page on uspto.gov within a frame.