Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor antagonist properties

U.S. Patent Number: 5350757

Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.

Inventors: Blankley; Clifton J. (Ann Arbor, MI), Hodges; John C. (Ann Arbor, MI), Klutchko; Sylvester (Ann Arbor, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/075,973

Issued: 1994-09-27

Expired: 2006-09-27

Classes: 514/307 ; 514/310

Field of search: 546/149,143,144,146,147,150 514/307,310

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