Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters

U.S. Patent Number: 5350845

Abstract: A process for the conversion of a 4-chlorosulfonyl azetidinone (a) to a 3-hydroxy-3-cephem-sulfoxide ester (d) by subjecting an intermediate comprising a tin containing Lewis acid-type Fiedel-Crafts catalyst and 3-exomethylene cepham to ozonolysis.

Inventors: Brown, Jr.; Frank (West Lafayette, IN)

Assignee: Eli Lilly and Company (Indianapolis, IN)

Application Number: 07/976,592

Issued: 1994-09-27

Expired: 2006-09-27

Classes: 540/215 ; 540/221; 540/222

Field of search: 540/215,222,221,228

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