3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [.beta.]thiophene-2-carboxamides as inhibitors of cell adhesion

U.S. Patent Number: 5356926

Abstract: 3-Alkyloxy-, aryloxy-, or arylalkyloxybenzo[b]-thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of preparation are also described.

Inventors: Boschelli; Diane H. (Plymouth, MI), Connor; David T. (Ann Arbor, MI), Wright; Clifford D. (Ann Arbor, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/015,005

Issued: 1994-10-18

Expired: 2006-10-18

Classes: 514/445 ; 549/52; 549/53; 549/54; 549/55

Field of search: 549/52,53,54,55 514/445

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