Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents

U.S. Patent Number: 5364861

Abstract: Optically pure isomers of 7-[3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl]quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating bacterial infections therewith. Also described is a method of manufacture of the quinolones and naphthyridones as well as the starting materials, the optically pure pyrrolidine moieties for attachment at the 7-position.

Inventors: Hagen; Susan E. (Canton Township, Wayne County, MI), Suto; Mark J. (Whitmore Lake, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/132,019

Issued: 1994-11-15

Expired: 2006-11-15

Classes: 514/300 ; 514/312; 546/123; 546/156

Field of search: 546/156,123 514/300,312

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