Cyclic amino acids and derivatives thereof

U.S. Patent Number: 5380925

Abstract: Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cyclic amino acid is treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.

Inventors: Beylin; Vladimir (Ann Arbor, MI), Chen; Huai G. (Ann Arbor, MI), Goel; Om P. (Ann Arbor, MI), Marlatt; Mark E. (Grass Lake, MI), Topliss; John G. (Ann Arbor, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/109,797

Issued: 1995-01-10

Expired: 2007-01-10

Classes: 562/443 ; 544/355; 546/135; 546/136; 546/169; 546/268.4; 546/269.7; 546/270.1; 546/270.7; 546/271.4; 546/272.1; 546/272.4; 546/275.4; 546/276.4; 546/277.4; 546/280.4; 546/280.7; 546/283.4; 548/217; 548/240; 548/253; 548/255; 549/475; 549/483; 549/59; 549/70; 560/19; 560/27; 560/38; 562/401; 562/403; 562/405; 564/168; 564/169; 564/189

Field of search: 562/401,403,405,443 560/19,27,38 564/168,169,189 549/59,70,483,475 548/217,255,240,253 546/135,169,268 544/355

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