Guanidino compounds as regulators of nitric oxide synthase

U.S. Patent Number: 5380945

Abstract: Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.

Inventors: Murad; Ferid (Lake Forest, IL), Kerwin; James F. (Grayslake, IL), Gorsky; Lee D. (Highland Park, IL)

Assignee: Abbott Laboratories (Abbott Park, IL)

Application Number: 08/159,972

Issued: 1995-01-10

Expired: 2007-01-10

Classes: 564/108 ; 564/104; 564/226; 564/227; 564/229

Field of search: 564/108,104,226,227,229 514/634

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