Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases

U.S. Patent Number: 5384318

Abstract: Compounds of the formula ##STR1## and pharmaceutical compositions comprising them, wherein R.sup.1, R.sup.2, R.sup.3, W, X and Z are as defined below. The compounds are inhibitors of 5-lipoxygenase enzyme and antagonists of leukotriene B4, leukotriene C4, leukotriene D4 and leukotriene E4.

Inventors: Eggler; James F. (Stonington, CT), Marfat; Anthony (Mystic, CT), Melvin, Jr.; Lawrence S. (Ledyard, CT), Masamune; Hiroko (Noank, CT)

Assignee: Pfizer Inc. (New York, NY)

Application Number: 07/835,997

Issued: 1995-01-24

Expired: 2007-01-24

Classes: 514/213.01 ; 514/266.2; 514/266.21; 514/266.23; 514/266.24; 514/312; 514/314; 514/367; 540/480; 540/481; 540/593; 544/283; 544/284; 546/153; 546/155; 546/165; 546/172; 546/175; 548/159

Field of search: 548/159 540/480,481,593 544/283,284 546/153,155,165,172,175 514/212,259,312,314,367

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