7-substituted quinolones and naphthyridones as antibacterial agents

U.S. Patent Number: 5384407

Abstract: A compound of the formula ##STR1## V, W, Y, and Z are each independently C--H, oxygen, nitrogen, or sulfur; T is C--H or nitrogen; n is 0 or 1; R.sup.4 is hydrogen or one, two or three substituents independently selected from C.sub.1 -C.sub.4 -alkyl, halo-substituted C.sub.1 -C.sub.4 -alkyl, hydroxy-substituted C.sub.1 -C.sub.4 -alkyl, halogen, hydroxy, C.sub.1 -C.sub.4 -alkoxy, mercapto, amino, mono-(C.sub.1 -C.sub.4 -alkyl)amino, di-(C.sub.1 -C.sub.4 -alkyl)amino, formamido, mono-(C.sub.1 -C.sub.4 -alkyl)amido, di-(C.sub.1 -C.sub.4 -alkyl)amido, cyano, nitro, C.sub.1 -C.sub.4 -alkoxycarbonyl, carboxyl, aminomethyl, mono-(C.sub.1 -C.sub.4 -alkyl)aminomethyl, di-(C.sub.1 -C.sub.4 -alkyl)aminomethyl, wherein free hydroxy and amino groups may be protected.

Inventors: Laborde; Edgardo (Canton, MI), Schroeder; Mel (Dexter, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/221,145

Issued: 1995-01-24

Expired: 2007-01-24

Classes: 544/298 ; 544/238; 544/322; 544/333; 544/334; 544/336; 544/408; 544/409; 546/276.4; 548/100; 548/125; 548/182; 548/183; 548/184; 548/202; 548/250; 548/251; 548/254; 548/316.4; 548/317.1; 548/326.5; 548/335.1; 548/517; 548/527; 548/577

Field of search: 544/238,298,322,333,334,336,408,409 546/281 548/100,125,182,183,184,202,250,251,254,316.4,317.1,326.5,335.1,517,518,527,566

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