3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamines and their derivatives, pharmaceutical compositions, and methods of use therefor

U.S. Patent Number: 5393923

Abstract: The present invention is a novel compound which is a 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamine or derivative thereof and a pharmaceutically acceptable acid addition or base salt thereof, pharmaceutical composition and methods of use therefor. The invention compounds are now found to have activity as inhibitors of one or both of cyclooxygenase and 5-lipoxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.

Inventors: Capiris; Thomas (Plymouth, MI), Connor; David T. (Ann Arbor, MI), Sircar; Jagadish C. (Ann Arbor, MI)

Assignee: Warner-Lambert Company (Morris Plains, NJ)

Application Number: 08/135,213

Issued: 1995-02-28

Expired: 2007-02-28

Classes: 564/28 ; 544/106; 544/358; 546/184; 549/29; 549/429; 560/24; 564/17; 564/215; 564/218; 564/223; 564/32; 564/47

Field of search: 564/26,28,47,215,218,223 568/706 544/106,358 546/184 548/206,215,356 549/29,429,306

Click the image above to view patent images at uspto.gov within a frame.

Click here for the fulltext page on uspto.gov within a frame.