Resolution of racemic indene oxide to yield (1S,2R)-indene oxide using Diplodia gossipina

U.S. Patent Number: 5849568

Abstract: A process is disclosed that hydrolyzes, by the action of an epoxide hydrolase of Diplodia gossipina (alternatively named Diplodia gossypina) ATCC 16391 or ATCC 10936, the undesired enantiomer of racemic indene oxide, an epoxide of indan.

Inventors: Chartrain; Michel M. (Westfield, NJ), Senanayake; Chris H. (North Brunswick, NJ), Rosazza; John P. N. (Iowa City, IA), Zhang; Jinyou (Edison, NJ)

Assignee: Merck & Co., Inc. (Rahway, NJ)

Application Number: 08/603,571

Issued: 1998-12-15

Expired: 2006-12-15

Classes: 435/280 ; 435/123

Field of search: 435/280,123

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